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West Nile, Ilheus, and Bunyamwera Virus Infections in Man^1,2,3,

West Nile, Ilheus and Bunyamwera viruses have been inoculated into patients with advanced inoperable neoplastic diseases in hopes of inhibiting the neoplasms. The course of infection of man by these viruses has not previously been known. Results of this study have been presented, with emphasis on the clinical picture and virology.

West Nile produced an asymptomatic infection in 5 of 21 patients inoculated.

Ilheus virus infected 9 of the 19 patients inoculated. It caused mild encephalitis in 3 patients, and in the other patients caused no symptoms.

Bunyamwera virus caused a very severe encephalitis with residual mental damage in one patient. It failed to infect 3 other patients.

There was no significant effect on growth of the neoplasms, but localization of virus in tumor tissue was demonstrated in some patients with each of the 3 viruses.

¹ From the Memorial Center for Cancer and Allied Diseases, New York 21, N. Y.

² This work was supported in part by grants from the National Cancer Institute of the U. S. Public Health Service, The Damon Runyon Memorial Fund for Cancer Research, and The American Cancer Society.

³ The authors wish to acknowledge the assistance of Marie Corazza, Ilene Shulman and Yvette Goldsmith in various phases of this study.

⁴ This work was carried out during tenure of a Damon Runyon Clinical Cancer Research Fellowship.