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The Cardiac Manifestations of Weil's Disease¹

Eight instances of definite myocardial involvement were observed in a group of 80 patients with Weil's disease. In 3 of these the only manifestations were electrocardiographic. Of the remaining 5, 3 showed irregularities and 2 congestive heart failure. All showed some type of electrocardiographic disturbance involving the T-waves. One additional patient showed extrasystoles only. Previous heart disease was unknown in each instance and follow-up studies showed complete recovery. The series gives some indication of the frequency of myocardial involvement and of the types of clinical cardiac pictures in severe icteric Weil's disease. Correlation of the cardiac findings with the course of the disease indicates that infectious myocarditis is the most likely cause of the cardiac changes. The possibility of chronic subclinical heart disease of other types as a contributory factor in this group appears unlikely. The possible participation of jaundice, uremia, and peripheral circulatory failure in these cases is discussed and evaluated.

¹ From the Department of Tropical Medicine and Public Health, School of Medicine, Tulane University of Louisiana and the Charity Hospital of Louisiana at New Orleans, Louisiana.