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Effect of Chloromycetin¹ on Experimental S. Typhosa Infection in Rabbits

In S. typhosa experimental infection in rabbits, Chloromycetin failed to abort an acute infection and when used as a curative agent in established infection (carrier state) in rabbits, its therapeutic effect was relatively low (30 per cent) following a single or repeated courses of treatment.

Blood serum levels of Chloromycetin in rabbits were relatively low and of short duration and this may in part account for the low prophylactic and curative effect of the antibiotic in rabbits.

The susceptibility of S. typhosa cultures to Chloromycetin on passage through untreated and Chloromycetin-treated rabbits, remained relatively unchanged.

Ox bile had no effect on sensitivity of S. typhosa culture to Chloromycetin and did not interfere with its action in vitro.

Empirical combined therapy of the S. typhosa carrier state in rabbits with Chloromycetin and one of the following agents: arsenoxide, a quinoline derivative, p-nitrobenzoate, p-nitrosalicylate, a sulfone derivative and dihydrostreptomycin, failed to produce additive therapeutic effect.

¹ Parke, Davis & Company trade mark for chloramphenicol.

² Research Laboratories, Joseph Campau Ave. at the River, Parke, Davis and Company, Detroit 32, Michigan.