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Mel B in the Treatment of Tryparsamide Resistant T. Gambiense Sleeping Sickness: Observations on Drug Resistance in the Trypanosomes of the French Cameroun^1,2,

1. Strains of trypanosomes are to be found in the French Cameroun which are resistant to tryparsamide only, or in addition to tryparsamide, to one, or several drugs of the group tartar emetic, orsanine, amidines, moranyl.

2. Ninety seven per cent out of 394 tryparsamide resistant patients responded favorably to treatments with Mel B; three per cent were Mel B resistant.

3. Mel B resistance occurs in the French Cameroun under two circumstances: (a) linked to tryparsamide resistance as an inherent character of certain strains of trypanosomes; (b) developed in the organism of infested humans, in the wake of an insufficient treatment with a compound containing the same phenylmelaminyl radical, as Mel B.

¹ From the Laboratory of Ernst A. H. Friedheim, 333 West 52nd St., New York 19, N. Y.

² In collaboration with the Sleeping Sickness Service of the French Cameroun. This study was carried out in the course of a research mission conferred on the author by the High Commissioner of the French Cameroun. The author is indebted to Colonel Beaudiment, Director of The Sleeping Sickness Service of the French Cameroun, for facilities granted.