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The Effect of Endochin on Experimental Toxoplasmosis^1,2,

A new drug, Endochin, is reported which possesses activity against experimental toxoplasmosis. Of the sulfa derivatives tested, sulfadiazine and Promin proved to have comparable or greater effect on the infection than Endochin. Other drugs selected for their activity against the exoerythrocytic stages of malaria and which proved to be ineffective in toxoplasmosis included a sulfanilanilide (SN 187), a metanilamide (SN 11,437), a naphthoquinone (SN 8557), an 8-amino-quinoline (SN 13,276), a biguanide (SN 12,837), and an acridone (DR 15,575). Treatment combining sulfadiazine and Endochin was no more efficacious than treatment with either drug by itself.

¹ This investigation was supported by a research grant from the National Institutes of Health, Public Health Service.

² The authors are pleased to acknowledge the assistance of Miss Joanna Hull and Dr. William J. Bruce.

³ University of Texas Medical School, Department of Bacteriology, Galveston, Texas.