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The Complement Fixation Test and other Findings in Malaria¹

The following résumé of findings in cases of malaria was prompted by the recently reported employment of Plasmodium vivax in the treatment of general paresis. Wagner-Jauregg (1) noting numerous reports of improvement in paresis resulting from infectious febrile conditions, first proposed Plasmodium vivax inoculation for the treatment of paresis in 1887 and later used Koch's tuberculin in doses at first small but in later cases quite large. Typhoid vaccine in large doses was also employed and both these gave varying degrees of improvement. In 1917 he inoculated several paretics with Plasmodium vivax and obtained a degree of improvement that warranted the continuation of the method. A soldier infected with benign tertian malaria and untreated with quinine, served as donor, and 1 to 4 cc. of his blood was injected subcutaneously into a group of paretics. They were permitted to have several chills, served as donors for other cases of paresis, and were then given quinine.

¹ Read by abstract at the nineteenth annual meeting of the American Society of Tropical Medicine, San Francisco, Calif., June 25, 26, 1923.