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The Effects of Oral Administration of Aureomycin, Sulfathiazole, Sulfamerazine and 4,4'-Diamino Diphenyl Sulfone on Toxoplasmosis in Mice¹

The protective properties of aureomycin hydrochloride, sulfamerazine, sodium sulfathiazole or 4,4'-diamino diphenyl sulfone have been demonstrated and compared by oral administration to mice inoculated with toxoplasma.

The sulfone provided a greater degree of protection than any of the others tested. Aureomycin and sulfathiazole afforded approximately equal protection while sulfamerazine was the least effective.

Since para-aminobenzoic acid failed to counteract the protective effect of aureomycin it appears that the mode of action of this antibiotic in preventing the death of toxoplasma-infected mice is different than that of sodium sulfathiazole or 4,4'-diamino diphenyl sulfone.

¹ This investigation was supported by a research grant from the Division of Research Grants and Fellowships of the National Institute of Health, U. S. Public Health Service.

² Department of Microbiology, School of Medicine, Indiana University, Indianapolis, Indiana.