HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Culbertson, J. T. Articles by Oliver-Gonzalez, J. Search for Related Content PubMed Articles by Culbertson, J. T. Articles by Oliver-Gonzalez, J.

The Chemotherapy of Human Filariasis by the Administration of Neostibosan¹

Second Report

Thirty patients infected with Wuchereria bancrofti were treated with neostibosan for from 33 to 48 days. After twelve months, 13 of the patients were free of circulating microfilariae and 5 others had lost from 87 to 99 per cent of their embryos, compared with the number in the blood before treatment. The twelve remaining patients showed little promise of eventual eradication of their infections after observation for nine months.

Of 15 control untreated patients infected with Wuchereria bancrofti, all remained infected for 14 months of observation. In this interval, 12 showed an over-all increase and 3 showed a decrease in the number of circulating microfilariae.

Among the treated patients, some of whom had been free of microfilariae for 12 months, none presented untoward symptoms referable to treatment.

¹ The work described in this paper was done in part under a contract, recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the College of Physicians and Surgeons, Columbia University.