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Am. J. Trop. Med., s1-25(4), 1945, pp. 345-348
Copyright © 1945 by American Journal of Tropical Medicine

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An Inquiry into the Growth Factor or Factors of Certain Blood and Tissue Flagellates1

Harry A. Senekjie AND Ruth A. Lewis
From the Department of Tropical Medicine Tulane University, New Orleans, La. in cooperation with the Tulane Amebiasis Unit of the National Institute of Health

1. The growth-promoting factor or factors for the blood and tissue flagellates studied are present in serum, but are not directly associated with albumin, euglobulin, pseudoglobulin or combinations of these three important fractions.
2. Neither hemoglobin nor washed erythrocytes contain the necessary stimulant.
3. This stimulant partially survives heating at 70°C. for 30 minutes, but is destroyed at 100°C.
4. The factor or factors are not para-aminobenzoic acid, pyridoxin, nicotinic acid, thiamin nor any other vitamins tested.
5. The essential stimulant is dialysable, and is probably lost during the process of fractionating the serum proteins.

Received November 24, 1944.
1 Aided by a research grant to the Department of Tropical Medicine, Tulane University, by Eli Lilly and Company. Thanks are extended to Dr. H. M. Powell, of the Biological Division, Eli Lilly and Company, for a generous supply of rabbit's serum albumin, serum euglobulin, and serum pseudoglobulin; to Dr. W. A. Jamieson, Director of Biological Research, Eli Lilly and Company, for supplying the vitamins used in this study; to the Curator of the American Type Culture Collection, Georgetown University, for a pure culture of Penicillium notatum, and to Doctors E. C. Faust and W. H. Wright for helpful suggestions during the course of the investigation and in preparation of this manuscript.

Read by Title at the Fortieth Annual Meeting of the American Society of Tropical Medicine, at St. Louis, Mo., November 13–16, 1944.






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Copyright © 1945 by the American Society of Tropical Medicine and Hygiene.