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Chemotherapy of Experimental Histoplasmosis in White Mice¹

1. Intravenous inoculation of white mice with Histoplasma capsulatum is a satisfactory method for the study of the disease in animals, and may be used in studying the chemotherapeutic effect of drugs.

2. The drugs sodium iodide, neostam, fuadin, sulfanilamide, proflavin, thymol, B-9 and sodium propionate were ineffective in the treatment of histoplasmosis in white mice, according to our criteria.

Received November 13, 1944.
¹ The data presented are taken from a thesis submitted to the Faculty of the Graduate School of the Medical College of Virginia in partial fulfillment of the requirement for the degree of Master of Science.

² Fellow in the division of Graduate Study, Medical College of Virginia, School of Dentistry.