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Spontaneous Histoplasmosis Occurring in a Dog¹

1. The third instance of a generalized infection in a dog by Histoplasma capsulatum is reported.

2. Material was not available for the cultivation or passage to other animals, but the morphologic characteristics and the reactions of the host are identical with previously described cases of this disease.

3. The importance of the occurrence of the disease in an animal pet in an area in which a number of human cases have been reported is stressed.

4. The possibility of the various methods of transmission from dog to man as postulated by De Monbreun is discussed.

5. The majority of evidence suggests either the respiratory or the gastro-intestinal tracts as the portal of entry.

Received June 29, 1944.
¹ The author is indebted to Dr. Oscar C. Zink, to whom the dog belonged, and to Dr L. S. Walsh, who performed the autopsy, for their permission to make this study.