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A Consideration of the Mechanism of Splenic Infarcts in Malaria¹

It is suggested that the infarcts occurring in the spleen in malaria may result from an obstruction produced by hyperplasia of the reticular-like cells located within the walls of the venous sinuses. Leucocytes and red blood cells may adhere to the surface of these masses of reticular-like cells since the circulation in malaria is slowed. The normal histological structures in the spleen of different animals are discussed that may predispose to vascular obstruction.

Received June 8, 1944.
¹ The material for the experimental observations and some of the human cases were obtained during the time I was at the University of Tennessee, other material was obtained from the Army Medical Museum through the courtesy of Col. Ash.

Research paper no. 555, Journal Series, University of Arkansas.