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Serological Studies of Bullis Fever

The clinical syndrome which is referred to as Bullis fever (1) and which is associated with a rickettsia-like agent (2) was further studied for serological identification or differentiation from some of the known rickettsial agents. The lack of relationship existing between the agent of Bullis fever and that of Rocky Mountain Spotted fever has been demonstrated by guinea pig challenge experiments (2). There has been some slight suggestion of similarity of the clinical picture to that of Q fever. This is not confirmed in the following report.

The majority of cases occurred in one (1) group of men, all stationed simultaneously at Camp Bullis, Texas, and coincidentally during a very high degree of insect infestation of the area. Two (2) months after the cessation of the outbreak, two hundred and sixty-one (261) serums were collected from cases which were diagnosed clinically as the Bullis fever syndrome.All of these cases gave a history of tick' and chigger bites,sudden onset of illness, severe headache, lymphadenopathy, and leukopenia.

¹ Colonel, Medical Corps, United States Army, and Captain, Veterinary Corps, Army of United States.