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The Complement Fixation Test in the Diagnosis of Yellow Fever

Use of Infectious Mouse Brain as Antigen¹

A complement-fixation test, using an antigen prepared from infectious mouse brains, is described for yellow fever.

The test has been shown to be biologically specific. Nonspecific reactions, however, tend to occur with Wassermann-positive sera, but these can usually be avoided by inactivating the sera at 65°C.

Complement-fixing antibodies were demonstrable in the serum of humans and monkeys recovered from infection with yellow fever virus. Following vaccination with the 17D strain, complement-fixing antibodies were uniformly present in monkey serum, but were detectable in only a small proportion of human sera. The application of this latter fact in making yellow fever surveys is discussed.

Received June 21, 1943.
¹ The studies on which this report is based were carried out under the auspices of the Serviço de Estudos e Pesquisas sobre a Febre Amarela, which is maintained jointly by the Ministry of Education and Health of Brazil and the International Health Division of The Rockefeller Foundation.