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Studies on the Effectiveness of Phenothiazine in Human Nematode Infections¹

1. Phenothiazine is an effective drug in the treatment of human Enterobius vermicularis infection. The drug has been given safely and successfully without noteworthy toxicity to more than 200 patients with this infection.

2. It is suggested that therapeutic doses be computed on the basis of body weight. A total dose of 300 mg./kg. of body weight administered during three days is suggested for further clinical trial. On this basis children 2–5 years of age are given up to a total of 5 grams; children 6–8 years 7.5 grams; and patients 9–13 years 10 grams; adults may be given 15 grams.

3. For the present its use should be limited to special clinical investigation, or to patients intolerant or refractory to gentian violet.

4. Phenothiazine, especially in large doses, is potentially toxic. Manifestations of poisoning are chiefly in the form of hemolytic anemia of various degrees and hepatitis.

5. Phenothiazine was found ineffective against infections with Ascaris lumbricoides, Necator americanus, Strongyloides stercoralis, and Trichocephalus trichiurus.

Received December 15, 1942.
¹ Read at the annual meeting of the American Society of Tropical Medicine, November 12, 1942, Richmond, Virginia.