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On the Therapeutic Interruption of Artificially Induced Malaria Infections^*

The reactivation of autochthonous malaria infections after presumably adequate specific therapy is a vexatious characteristic frequently observed, the reason for which is at present obscure. The only clear fact emerging in such instances is that presumably adequate quantities of a specific parasiticidal drug have failed to eradicate the infection. On the other hand, we have observed that artificially induced vivax infections are extremely sensitive to treatment.

In a series of 107 vivax infections from local strains induced by intravenous inoculation with infected blood, we have had occasion to interfere with, or terminate, the infection in 27 patients. In 14 of these instances the inoculation was the primary experience of the patient with malaria on our service, while 13 were instances of reinoculation.

In 11 instances termination was effected by full therapeutic courses, consisting of 14 grams of quinine given in divided doses over a 7 day period. In another instance a therapeutic course totalling 10 grams produced a similar result.

Received October 23, 1942.
^* The studies and observations on which this paper is based were conducted with the support and under the auspices of the International Health Division of The Rockefeller Foundation, in cooperation with the Florida State Board of Health and the Florida State Hospital.