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A Study of the Pathological Lesions in P. Knowlesi Infection in M. Rhesus Monkeys^*

The pathological changes are reported in the tissues of 26 Macacus rhesus monkeys infected with P. knowlesi that were either killed or died during the acute phase of the disease.

The lesions observed are the same as those described by other investigators in various types of malaria and in different animal species.

The presence of a dilatation of the cavities of the heart, edema of the lungs, dilatation of the sinusoids around the central veins of the liver, necrosis of the hepatic cells about the central veins and parenchymatous degeneration of the kidneys indicate that anoxemia may be the important factor in the cause of death.

It is suggested that the severity of the anemia, the percentage of parasitization, and the rapidity with which the disease progresses, all influence the development of myocardial failure, hepatic necrosis and edema of the lungs in monkeys infected with Plasmodium knowlesi.

Received December 30, 1942.
^* This is a report of one of the Pathological studies made upon material used in the Cooperative studies in Malaria by The University of Tennessee & Tennessee Valley Authority.

Read in part before the American Society of Tropical Medicine in St. Louis, Missouri, November 13, 1941.