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The Vesicular Test

Diagnostic Method of Infection by Poradenic (Lymphogranuloma Inguinale) Virus¹

Frei's test links, nowadays, many different pathological processes nosologically classified as the Sixth Venereal Disease. It has been advanced that the infection by poradenic virus should be considered a general disease with three periods, like syphilis, and with anatomical changes more or less limited to the rectogenital area, although extra-genital localizations have been described.

The study of patients suspected of poradenic virus infection is sometimes difficult because the Frei's antigen is not always at hand; the buboes may be scarce and the activity of the antigen is limited. To overcome these difficulties, antigenic animal sources have been suggested, created by artificial infection of laboratory animals, and such sources now exist in the market ape and white mouse. In my routine work the ape antigen has proved to be not so reliable as the human antigen. Efforts have been made by others to prepare an antigen from the intestinal mucous membrane or from the human blood serum of patients.

Received September 10, 1940.
¹ This paper presents a phase of a personal research work on poradenic virus. The investigation has been made possible by a favorable combination of circumstances that assured the kindly coöperation of the following co-workers:

Dr. E. Noguera Gómez, Director of the Laboratory of Chemistry, in the National Health Office, who has devised a simple and accurate technic for the concentration of the cerebro-spinal fluid.

Prof. Dr. R. Jaffé, Chief of the Pathological Department in Moabit Hospital, in Berlin, now on the staff of the Pathological Department of the Hospital Vargas, who did the studies of the biopsies and white mouse brains.

Prof. Dr. Martin Mayer, formerly a Member of the Tropen Institut, in Hamburg, now working in our Instituto Nacional de Higiene, has done the work pertaining to white mouse inoculation and cyto-bacteriologic study of the blister fluid.

Dr. Martin Vegas, a well-known Venezuelan skin specialist, provided me with Frei's antigen, made in his Laboratory, offering, besides, valuable suggestions concerning different dermatologic possibilities in connection with the test. I am grateful to them.