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A Comparison of High and Low Subcultures of Yellow Fever Vaccine (17D) in Human Groups¹

Comparative tests carried out in human groups under laboratory conditions failed to show any significant difference in the immunizing efficiency of high (450th) and low (212th) culture passage material of yellow fever virus 17D, when comparable dosages of virus were used. With dosages of virus approaching 100 m.l.d. for mice, some individuals fail to produce demonstrable antibodies. Other persons, however, show definite immunity after as little as 10 m.l.d. for mice of either high or low subculture virus.

Received May 8, 1941.
¹ The studies and observations on which this paper is based were conducted with the support and under the auspices of the Section of Special Studies maintained by the Ministry of Labor, Hygiene, and Social Welfare of the Republic of Colombia and the International Health Division of The Rockefeller Foundation.