HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vedder, E. B. Search for Related Content PubMed Articles by Vedder, E. B.

Beriberi or Inanition?

II. THE ADMINISTRATION OF VITAMIN B₁ TO RATS RECEIVING UNBALANCED DIETS

A connection between vitamin B and carbohydrate metabolism was claimed by Funk in 1914 (1), and Hartwell (2) in 1924 claimed a quantitative relation between protein and vitamin B. These and similar experiments were performed with yeast or other impure vitamin B concentrates, and it was thought desirable to conduct experiments to determine whether the pure crystalline vitamin B₁ is concerned in the metabolism of protein, fat or carbohydrate, and further to produce inanition by using diets of fat and carbohydrate, though with an ample supply of vitamins, and to study possible changes in the nerves.

1. Eight rats of approximately 50 grams weight were fed on protein as follows:
grams
Casein, freed of vitamin B₁ 81
Lean raw beef, twice a week 5
Osborne and Mendel salt mixture 4
Autoclaved yeast 10 (source of B₂)
Jewfish liver oil 0.5 (source of A and D)

2. Eight similar rats were fed on carbohydrate as follows:
grams
Cornstarch 81
Osborne and Mendel salt mixture 4