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The Infection of Reticulocytes by Plasmodium Vivax¹

Findings are presented based on a systematic and comparative study of the parasitic invasion of reticulocytes and mature erythrocytes in two patients experiencing moderately long, spontaneously-terminating vivax infections.

Plasmodium vivax showed a definitely greater tendency to invade reticulocytes rather than mature erythrocytes, even in the face of a much larger available number of the latter. This applied to multiple as well as single infections.

A well-defined reticulocytosis developed during the latter part of the infections; about this time the terminal drop in the parasite density commenced. Spontaneous termination of the attack preceded the return of the immature erythrocytes to normal numbers.

Received October 5, 1937.
¹ The studies and observations on which this paper is based were conducted with the support and under the auspices of the International Health Division of The Rockefeller Foundation, in coöperation with the Florida State Board of Health and the Florida State Hospital.