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Invasion of the Submucosa of the Human Small Intestine by Ancylostoma Braziliense

Description of five cases of infection of the submucosa of the wall of the small intestine in native Malays in Batavia, Java, by a nematode which in one case was recognized by Sandground as Ancylostoma braziliense. The wandering worm causes considerable tissue damage in the form of local hemorrhage and inflammation characterized by eosinophilia. The worm deposits eggs in large numbers in the jejunal submucosa. In due time these eggs embryonate and larvae escape. The ultimate fate of these larvae and of the adult worms is unknown.

In one patient who died from purulent peritonitis there was a perforation in the jejunum of obscure origin; the possibility of Ancylostoma braziliense acting as a causative agent for this type of perforation must be considered.

Received April 21, 1937.