HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wood, F. D. Search for Related Content PubMed Articles by Wood, F. D.

Natural and Experimental Infection of Triatoma Protracta Uhler and Mammals in California with American Human Trypanosomiasis¹

1. The blood-sucking bug, Triatoma protracta Uhler, and the wood rat, Neotoma fuscipes macrotis Thomas are natural carriers of Trypanosoma cruzi Chagas in southern California.

2. The following animals have been experimentally infected with this trypanosome: albino rats, albino mice, rhesus monkeys, a puppy, an opossum (Didelphis virginiana virginiana Kerr), 2 species of dusky-footed wood rats (Neotoma fuscipes annectens Elliot and N. f. macrotis Thomas), and 5 species of white-footed mice (Peromyscus eremicus fraterculus [Miller], P. californicus insignis Rhoads, P. californicus californicus [Gambel], P. maniculatus gambeli [Baird], P. truei gilberti [Allen]).

3. The San Diego desert and southern parasitic mice and the Virginia opossum have all been found in wood rat nests in the infected locality, so it is possible that they, too, are carriers.

4. Leishmania bodies were seen in bone marrow, cardiac and voluntary muscle of infected animals.

5. Lesions composed of infiltration lymphocytes, monocytes, and plasma cells have been found in cardiac and voluntary muscles, cerebrum, and meninges.

6. Animals infected by this strain take light infections, showing few parasites or lesions and usually no symptoms.

7. Neither splenectomy, injection of testicle extract, nor increased temperature have any intensifying effect upon the infection.

8. Varying the host species gave progressively shorter incubation periods, indicating a stimulating effect upon the parasite.

9. One out of five attempts to reinfect animals succeeded, indicating a partial immunity.

10. This trypanosome has been cultured on semi-solid blood agar, the culture forms being comparable to the insect phase.

¹ The writer wishes to express appreciation to Professor C. A. Kofoid of the Department of Zoology for his stimulating interest and supervision of this work. Grateful acknowledgment is also extended to Professor K. F. Meyer of Hooper Foundation for Medical Research for his valuable advice, especially in the diagnosis of pathological tissue changes, to Professor W. B. Herms of the Department of Entomology for identification of insects, and to Professor J. Grinnell and his associates in the Museum of Vertebrate Zoology for identification of mammals.