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The Differential Pathology of Dysentery¹

1. The pathology of lesions of dysentery is determined by the parasite, protozoon or bacterium causing it.

2. The pathology of infection with Endamoeba histolytica is characterized by lysis of tissue cells, leucocytes and red blood corpuscles with little or no inflammatory reaction until and unless secondary bacterial infection of the lesions occurs.

3. The pathology of infection with Balantidium coli is characterized by traumatic injury to the intestinal mucosa and secondary infection of the traumatized areas by bacteria carried in by the parasite.

4. The pathology of infection by bacteria of the dysentery and food poisoning group is acute inflammation, the intensity of which varies over a wide range.

5. The differentiation of the kinds of dysentery requires a consideration of the characteristic action of the etiologic agent which is mirrored by the epidemiology, clinical picture, cytology of the exudate,and confirmed by the pathological anatomy.

President's address, Twenty-Ninth Annual Meeting, American Society of Tropical Medicine, November 15, 16 and 17, 1933.