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A Case of Histoplasmosis of Darling in an Infant¹

A case of fungus infection (histoplasmosis of Darling (1)) is reported in an infant in Tennessee.

The diagnosis was made from the blood during life by finding the characteristic parasite in the large mononuclear cells.

It seems probable that the part played by the large mononuclear cells in the plugging of blood vessels, in the collapse of the alveoli of the lungs, in the massive invasion of the bone marrow and in the destruction of red cells, may explain many of the symptoms of the disease.

The identity of the invading organism has been established in the Department of Pathology of this institution.

¹ Read at the twenty-ninth annual meeting of the American Society of Tropical Medicine at Richmond, November 15, 16 and 17, 1933.

The authors wish to thank Dr. Henry E. Meleney of the Department of Preventive Medicine and Public Health for his very considerable help and interest in the identification of the invading organism.