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Bactericidal Action of Di-Hydranol in Human Cholera Carriers¹

In 1924 Veador Leonard introduced into the practice of medicine a hexyl derivative of resorcinol as a urinary antiseptic which has since come into use under the name "caprokol." Several years later (Leonard and Feirer, 1931) the next higher homologue, heptyl resorcinol, was developed by him as an intestinal antiseptic. This is called di-hydranol. Its chemical name is 2-4-dihydroxyphenyl-n-heptane. Experiments of Leonard have shown that increase in the weight of the alkyl chain resulted in greater bactericidal power of the drug without apparent increase in toxicity when administered to rabbits.

Because of a small outbreak of cholera in Manila in 1930, it was thought opportune to try the sterilizing power of di-hydranol on cholera carriers.

Through the permission of the Director of Health and the Director of the San Lazaro Hospital and the coöperation of its resident physicians, Drs. A. Barcelon-Guevara and E. Roxas-Pineda, experiments were carried out on 70 patients.

¹ From the Department of Parasitology, School of Hygiene and Public Health, University of the Philippines, Manilla, P. I.