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Am. J. Trop. Med. Hyg., 79(2), 2008, pp. 262-266
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Humoral Immune Response of Dengue Hemorrhagic Fever Cases in Children from Tegucigalpa, Honduras

Ivette Lorenzana De Rivera, Leda Parham, Wendy Murillo, Walter Moncada, AND Susana Vazquez*
Department of Microbiology, National Autonomous University of Honduras, Tegucigalpa, Honduras; Social Security Hospital of Honduras, Tegucigalpa, Honduras; "Pedro Kourí" Institute, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Havana City, Cuba

The humoral immune response in Honduran dengue hemorrhagic fever (DHF) hospitalized pediatric cases from the epidemics of 2004 and 2005 was studied in sera collected from 5 to 7 days of fever onset. A total of 145 cases were included in the study: 40 classified as primary with DHF Grade I or II and 86 classified as secondary; from them, 73 were DHF Grade I or II and 13 were dengue shock syndrome (DSS) Grade III or IV. The highest number of primary cases was found in children < 1 year of age. The highest number of secondary cases was observed in children between 5 and 10 years of age. The IgA values showed a statistically significant difference between primary and secondary groups. The relationship between antibody responses and severity grade is discussed. This is the first study related to the humoral immune response and severity grade in DHF cases in Honduran children.

Received October 17, 2007. Accepted for publication May 13, 2008.

Financial support: This work was performed as part of the Project "A Comprehensive Multidisciplinary Study on the Epidemiology of the Hemorrhagic Fevers–Leptospirosis and Dengue–in Central America" Grant ICA4-CT-2001-10086.

* Address correspondence to Susana Vazquez, "Pedro Kourí" Institute, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Autopista Novia del Mediodía, Km 6 1/2, La Lisa, Ciudad de la Habana, P.O. Box: 601 Marianao 13, Cuba. E-mail: svazquez{at}ipk.sld.cu

Authors’ addresses: Ivette Lorenzana De Rivera, Leda Parham, Wendy Murillo, Department of Microbiology, National Autonomous University of Honduras. Tegucigalpa, Honduras. Walter Moncada, Social Security Hospital of Honduras, Tegucigalpa, Honduras. Susana Vazquez, "Pedro Kourí" Institute, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Havana City, Cuba, Autopista Novia del Mediodía, Km 6 1/2, La Lisa, P.O. Box 601, Marianao 13, Ciudad de la Habana, Cuba, Tel and Fax: 53-7-2020450-2046051, E-mail: svazquez{at}ipk.sld.cu.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.