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Am. J. Trop. Med. Hyg., 78(6), 2008, pp. 968-972
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Comparative Analysis of Nucleotide Sequences of Orientia tsutsugamushi in Different Epidemic Areas of Scrub Typhus in Shandong, China

Li-Ping Yang, Zhong-Tang Zhao*, Zhong Li, Xian-Jun Wang, Yun-Xi Liu, AND Peng Bi
Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, People’s Republic of China; Department of Prevention and Control of Infectious Disease, Shandong Center for Disease Control and Prevention, Jinan, People’s Republic of China; Department of Nosocomial Infection Management and Disease Control, Institute of Hospital Management, General Hospital of PLA, Beijing, People’s Republic of China; Department of Public Health, School of Population Health and Clinical Practice, The University of Adelaide, Adelaide, Australia

Scrub typhus, caused by Orientia tsutsugamushi, is a zoonosis that spreads rapidly in Shandong, China. To investigate the molecular characterization of O. tsutsugamushi in new and old epidemic areas in Shandong Province, we compared the genetic relationships of O. tsutsugamushi between Linyi and Tai’an districts, typical old and new epidemic areas in Shandong, respectively. O. tsutsugamushi was detected in blood from 12 of 16 patients in Linyi and in eschar from 3 of 4 patients in Tai’an; 17 of 128 rodents were found to be infected with O. tsutsugamushi in Linyi, and 4 of 68 rodents were found to be O. tsutsugamushi-positive in Tai’an. The results indicated less genetic variation in O. tsutsugamushi between the new and old epidemic areas, and the Sdu-1 type, similar to Japan Kawasaki, was the main genotype of O. tsutsugamushi in Shandong Province.

Received September 3, 2007. Accepted for publication March 1, 2008.

Financial support: This study supported by the National Natural Science Foundation of China (No. 30371237) and the Specialized Research Fund for the Doctoral Program of Higher Education of Ministry of Education, China (No. 20050422052).

* Address correspondence to Zhong-Tang Zhao, Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012, People’s Republic of China. E-mail: ztzhao{at}sdu.edu.cn

Authors’ addresses: Li-Ping Yang and Zhong-Tang Zhao, Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, 44 Wenhua Xi Road, Jinan 250012, People’s Republic of China, Tel: 86-531-88382128, Fax: 86-531-88382553, E-mail: ztzhao{at}sdu.edu.cn. Zhong Li and Xian-Jun Wang, Department of Prevention and Control of Infectious Disease, Shandong Center for Disease Control and Prevention, Jinan 250014, People’s Republic of China. Yun-Xi Liu, Department of Nosocomial Infection Management and Disease Control, Institute of Hospital Management, General Hospital of PLA, Beijing 100853, People’s Republic of China. Peng Bi, Department of Public Health, School of Population Health and Clinical Practice, The University of Adelaide, Adelaide SA 5005, Australia.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.