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Am. J. Trop. Med. Hyg., 78(5), 2008, pp. 803-805
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


A Doxycycline Hyclate Rodent Bait Formulation for Prophylaxis and Treatment of Tick-transmitted Borrelia burgdorferi

Marc C. Dolan*, Nordin S. Zeidner, Elizabeth Gabitzsch, Gabrielle Dietrich, Jeff N. Borchert, Rich M. Poché, AND Joseph Piesman
Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, Fort Collins, Colorado; Genesis Laboratories Incorporated, Wellington, Colorado

 

ABSTRACT

The prophylactic and curative potential of doxycycline hyclate formulated in a rodent bait at concentrations of 250 and 500 mg/Kg was evaluated in a murine model of Lyme borreliosis. Both bait formulations prevented tick-transmitted Borrelia burgdorferi infection in 100% of C3H/HeJ mice (N = 16), as well as cured acute, established infection in mice (N = 8) exposed to bait for 14 days. Spirochete infection was cleared in 88.9% to 100% of infected nymphs feeding on mice fed 250 and 500 mg/Kg antibiotic bait formulations, respectively. These data provide evidence for exploring alternative techniques to prevent transmission of Lyme disease spirochetes.

Received January 16, 2008. Accepted for publication February 15, 2008.

Disclaimer: Author Richard M. Poché is an inventor on a United States Patent #5,932,437 "Control of Lyme Disease Spirochetes", related to this work. Doxycycline-treated bait used in these studies was provided by Genesis Laboratories, Inc., Wellington, CO 80549. The findings and conclusions of this study are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Mention of a method or a product does not constitute an endorsement.

Animals were handled according to approved protocols on file with the Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases Animal Care and Use Committee.

* Address correspondence to Marc C. Dolan, Centers for Disease Control and Prevention, Division of Vector-Borne Infectious Diseases, 3150 Rampart Rd, Fort Collins, CO 80521. E-mail: mcd4{at}cdc.gov

Authors’ addresses: Marc C. Dolan, Nordin S. Zeidner, Elizabeth Gabitzsch, Gabrielle Dietrich, and Joseph Piesman, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80521. Jeff N. Borchert and Rich M. Poché, Genesis Laboratories Incorporated, P.O. Box 1195, Wellington, CO 80549.

Reprint requests: Marc C. Dolan, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, Fort Collins, CO 80521.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.