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Am. J. Trop. Med. Hyg., 78(5), 2008, pp. 770-776
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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Decreased Serum Paraoxonase-1 Activity during Intestinal Nematode (Nippostrongylus brasiliensis) Infection in Rats

Ayman Samir Farid, Keiko Nakahara, Noboru Murakami, Toshiharu Hayashi, AND Yoichiro Horii*
Veterinary Teaching Hospital and Parasitology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan; Laboratory of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan; Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Yamaguchi, Yamaguchi, Japan

Reduced paraoxonase-1 (PON1) activity has been observed in a number of pathological conditions; however, little is known about the effects of intestinal nematode infections, such as Nippostrongylus brasiliensis, on paraoxonase activity. We observed a significant reduction in serum paraoxonase and arylesterase activity after N. brasiliensis infection in Wistar rats from Day 6 until Day 12 post-infection (p.i.) for serum paraoxonase and from Day 3 until Day 24 p.i. for arylesterase. In addition, N. brasiliensis infection increased serum concentrations of pro-inflammatory cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-{alpha}), with maximum concentrations observed on Day 9 p.i. These cytokines are known to inhibit the synthesis of hepatic PON1 mRNA. Thus, the observed reduction in PON1 activity during N. brasiliensis infection is likely associated with inflammatory reactions mounted against the parasites.

Received November 2, 2007. Accepted for publication February 27, 2008.

Financial support: A.S.F. received financial support from the Egyp-tian government for Scholarship of PhD degree.

* Address correspondence to Yoichiro Horii, Veterinary Teaching Hospital and Parasitology, Faculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai, Nishi 1-1, Miyazaki 889-2192, Japan. E-mail: horii{at}cc.miyazaki-u.ac.jp

Authors’ addresses: A. S. Farid and Y. Horii, Veterinary Teaching Hospital and Parasitology, Faculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai, Nishi 1-1, Miyazaki 889-2192, Japan, E-mails: aymansf{at}yahoo.com and horii{at}cc.miyazaki-u.ac.jp. K. Na-kahara and N. Murakami, Laboratory of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai, Nishi 1-1, Miyazaki 889-2192, Japan, E-mails: a0d201u{at}cc.miyazaki-u.ac.jp and a0d209u{at}cc.miyazaki-u.ac.jp T. Hayashi, Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Yamaguchi, 1677-1 Yoshida, Yamaguchi 753-8515, Japan, E-mail: hayasi{at}yamaguchi-u.ac.jp.

Reprint requests: Veterinary Teaching Hospital and Parasitology, Faculty of Agriculture, University of Miyazaki, Gakuen-Kibanadai, Nishi 1-1, Miyazaki 889-2192, Japan.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.