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Am. J. Trop. Med. Hyg., 78(4), 2008, pp. 641-642
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Pharmacokinetics of Dihydroartemisinin in a Murine Malaria Model

Kevin T. Batty*, Peter L. Gibbons, Timothy M. E. Davis, AND Kenneth F. Ilett
School of Pharmacy, Curtin University of Technology, Bentley, Western Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia

 

ABSTRACT

Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 L/hr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic–pharmacodynamic evaluations of DHA in murine models.

Received July 7, 2007. Accepted for publication January 2, 2008.

Financial support: This work was supported by the National Health and Medical Research Council of Australia (NHMRC New Investigator Grant 141103 to K.T.B.).

* Address correspondence to Kevin T. Batty, School of Pharmacy, Curtin University of Technology, G.P.O. Box U1987, Perth, Western Australia 6845, Australia. E-mail: kevin.batty{at}curtin.edu.au

Authors’ addresses: Kevin T. Batty and Peter L. Gibbons, School of Pharmacy, Curtin University of Technology, G.P.O. Box U1987, Perth, Western Australia 6845, Australia, Telephone: +61 8 9266 7369, Fax: +61 8 9266 2769, E-mails: Kevin.Batty{at}curtin.edu.au and P.Gibbons{at}curtin.edu.au. Timothy M. E. Davis, School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, P.O. Box 480, Fremantle, Western Australia 6959, Australia, Telephone: +61 8 9431 3229, Fax: +61 8 9431 2977, E-mail: tdavis{at}cyllene.uwa.edu.au. Kenneth F. Ilett, Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia 6009, Australia, Telephone: +61 8 9346 2985, Fax: +61 8 9346 3469, E-mail: ken.ilett{at}uwa.edu.au.






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.