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Am. J. Trop. Med. Hyg., 78(2), 2008, pp. 348-351
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Phylogenetically Distinct Hantaviruses in the Masked Shrew (Sorex cinereus) and Dusky Shrew (Sorex monticolus) in the United States

Satoru Arai, Shannon N. Bennett, Laarni Sumibcay, Joseph A. Cook, Jin-Won Song, Andrew Hope, Cheryl Parmenter, Vivek R. Nerurkar, Terry L. Yates, AND Richard Yanagihara*
Department of Tropical Medicine, Medical Microbiology and Pharmacology, and Department of Pediatrics, John A. Burns School of Medicine, University of Hawai‘i at Manoa, Honolulu, Hawai‘i; Museum of Southwestern Biology, University of New Mexico, Albuquerque, New Mexico; Department of Microbiology, College of Medicine, Korea University, Seoul, Korea

 

ABSTRACT

A limited search for hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne hantaviruses, named Ash River virus and Jemez Springs virus, respectively, challenges the long-held dogma that rodents are the sole reservoir hosts and forces a re-examination of their co-evolutionary history. Also, studies now underway are aimed at clarifying the epizootiology and pathogenicity of these new members of the genus Hantavirus.

Received July 2, 2007. Accepted for publication October 21, 2007.

Acknowledgments: The authors thank the staff of the Greenwood Molecular Biology Facility, Pacific Biosciences Research Center, for excellent technical assistance with DNA sequencing. This work was supported in part by grants P20RR018727 (Centers of Biomedical Research Excellence) and G12RR003061 (Research Centers in Minority Institutions) from the National Center for Research Resources, National Institutes of Health. Shrew samples from Alaska were collected through support of grants DEB0196095 and DEB9981915 from the National Science Foundation.

* Address correspondence to Richard Yanagihara, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawai‘i at Manoa, 651 Ilalo Street, BSB320L, Honolulu, HI 96813. E-mail: yanagiha{at}pbrc.hawaii.edu

Authors’ addresses: Satoru Arai, Shannon N. Bennett, Laarni Sumibcay, Vivek R. Nerurkar, and Richard Yanagihara, Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawai‘i at Manoa, 651 Ilalo Street, BSB320, Honolulu, HI 96813, Tel: (808) 692-1610, Fax: (808) 692-1976. Joseph A. Cook, Andrew Hope, Cheryl Parmenter, and Terry L. Yates, Museum of Southwestern Biology, MSC03 2020, University of New Mexico, Albuquerque, NM 87131-0001, Tel: (505) 277-1360, Fax: (505) 277-1351. Jin-Won Song, Department of Microbiology, College of Medicine, Korea University, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-705, Korea, Tel: 82 (2) 920-6408; Fax: 82 (2) 923-3645.




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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.