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Am. J. Trop. Med. Hyg., 78(2), 2008, pp. 208-209
Copyright © 2008 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


Consensus Guidelines for Dosing of Amoxicillin-Clavulanate in Melioidosis

Allen C. Cheng, Wirongrong Chierakul, Wipada Chaowagul, Ploenchan Chetchotisakd, Direk Limmathurotsakul, David A. B. Dance, Sharon J. Peacock, AND Bart J. Currie*
Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Department of Medicine, Srinagarind Hospital, Khon Kaen Universty, Khon Kaen, Thailand; Health Protection Agency South West, United Kingdom; Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom; Royal Darwin Hospital, Darwin, Australia

 

ABSTRACT

Melioidosis is an infectious disease endemic to northern Australia and Southeast Asia. In response to clinical confusion regarding the appropriate dose of amoxicillin-clavulanate, we have developed guidelines for the appropriate dosing of this second-line agent. For eradication therapy for melioidosis, we recommend 20/5 mg/kg orally, three times daily.

Received June 13, 2007. Accepted for publication July 28, 2007.

Financial support: AC is supported by a NHMRC postdoctoral fellowship and SJP is supported by a Wellcome Trust Career Development Award.

* Address correspondence to Bart J. Currie, Menzies School of Health Research, PO Box 41096, Casuarina NT 0811. E-mail: bart{at}menzies.edu.au

These Guidelines were developed as a consensus amongst a group of clinicians with extensive experience of treating melioidosis in the endemic regions of Thailand and Australia.

Authors’ addresses: Allen C. Cheng, Department of Medicine, University of Melbourne, c/- 9th floor, Royal Melbourne Hospital, Parkville VIC 3052, Australia, E-mail: allen.cheng{at}menzies.edu.au. Wirongrong Chierakul, Direk Limmathurotsakul, and Sharon J. Peacock, Faculty of Tropical Medicine, Mahidol University, Rajvithi Road, Bangkok, E-mails: kae{at}tropmedres.ac, direk{at}tropmedres.ac, and Sharon{at}tropmedres.ac. Wipada Chaowagul, Sappasithiprasong Hospital, Sappasit Road, Ubon Ratchathani, E-mail: vipada_1{at}yahoo.com. Ploenchan Chetchotisakd, Department of Medicine, Srinagarind Hospital, Khon Kaen University, Khon Kaen, E-mail: ploencha{at}kku.ac.th. David A. B. Dance, Health Protection Agency South West, Tamar Science Park, 1 Davy Road, Derriford, Plymouth PL6 8BX, E-mail: david.dance{at}phnt.swest.nhs.uk.

Reprint requests: Bart J. Currie, Menzies School of Health Research, PO Box 41096, Casuarina NT 0811. E-mail: bart{at}menzies.edu.au






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Copyright © 2008 by the American Society of Tropical Medicine and Hygiene.