AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 77(3), 2007, pp. 447-450
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mytton, O. T.
Right arrow Articles by Nosten, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mytton, O. T.
Right arrow Articles by Nosten, F.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Arrhythmia
Related Collections
Right arrow Malaria

SHORT REPORT


Electrocardiographic Safety Evaluation of Dihydroartemisinin–Piperaquine in the Treatment of Uncomplicated falciparum Malaria

Oliver T. Mytton, Elizabeth A. Ashley, Leon Peto, Ric N. Price, Yar La, Rae Hae, Pratap Singhasivanon, Nicholas J. White, AND François Nosten*
Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom; Menzies School of Health Research, Charles Darwin University, Darwin, Australia, Epicentre, Paris, France

 

ABSTRACT

Dihydroartemisinin–piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett’s correction) were 2 (–6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram.

Received December 9, 2006. Accepted for publication May 6, 2007.

Acknowledgments: We thank all the patients and staff of the Shoklo Malaria Research Unit who participated in these studies.

Financial support: The studies were partially supported by the Medicines for Malaria Venture (MMV). The Shoklo Malaria Research Unit is part of the Mahidol–Oxford Tropical Medicine Research Unit funded by the Wellcome Trust of Great Britain.

* Address correspondence to François Nosten, Shoklo Malaria Research Unit, 68/30 Ban Toong Road, P.O. Box 46, Mae Sot, 63110, Tak, Thailand. E-mail: smru{at}tropmedres.ac

Authors’ addresses: Oliver T. Mytton, Elizabeth A. Ashley, Leon Peto, Yar La, Rae Hae, and François Nosten, Shoklo Malaria Research Unit, P.O. Box 46 Mae Sot, Thailand; Telephone: +66 55 545 021, E-mail: SMRU{at}tropmedres.ac. Elizabeth A. Ashley, Nicholas J. White, Pratap Singhasivanon, and François Nosten, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Nicholas J. White, Elizabeth A. Ashley, and François Nosten, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom. Ric N. Price, Menzies School of Health Research, Charles Darwin University, Darwin, Australia. Elizabeth A. Ashley, Epicentre, Paris, France.

Reprint requests: François Nosten, Shoklo Malaria Research Unit, 68/30 Ban Toong Road, P.O. Box 46, Mae Sot, 63110, Tak, Thailand, Telephone: +66 55 545021, Fax: +66 55 545020. E-mail: smru{at}tropmedres.ac.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.