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Am. J. Trop. Med. Hyg., 77(1), 2007, pp. 118-120
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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Right arrow Melioidosis

Variable Presentation of Neurological Melioidosis in Northeast Thailand

Direk Limmathurotsakul*, Wipada Chaowagul, Prawatwong Wongsrikaew, Arhtitpong Narmwong, Nicholas P. Day, AND Sharon J. Peacock
Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Department of Medicine and Department of Neurosurgery, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

We describe three instructive cases of neurologic melioidosis that demonstrate the variable nature of clinical manifestations and disease pathology. The appropriate duration and choice of parenteral and oral antimicrobial therapy for neurologic melioidosis are also discussed.

Received January 30, 2007. Accepted for publication March 23, 2007.

Acknowledgments: The authors thank the director of Sappasithiprasong Hospital, together with the medical and nursing staff of the Medical and out-patient department; the staff of the Wellcome Trust–Oxford University–Mahidol University Tropical Medicine Research Program; Vanaporn Wuthiekanun, Gumphol Wongsuvan, Aunchalee Thanwisai, and Narisara Chantratita for laboratory data, including genotyping; and Nongluk Getchalarat and Jintana Suwannapruk for their technical assistance.

Financial support: This study was funded by the Wellcome Trust.

Disclosure: No conflicts of interest are reported by any author.

* Address correspondence to Direk Limmathurotsakul, Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, 10400, Thailand. E-mail: direk{at}tropmedres.ac

Authors’ addresses: Direk Limmathurotsakul, Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, 10400, Thailand, Telephone: +66 2 354 1395, Fax: +66 2 354 9169, E-mail: direk{at}tropmedres.ac. Wipada Chaowagul, Prawatwong Wongsrikaew, and Arhtitpong Narmwong, Sappasithiprasong Hospital, Ubon Ratchathani Hospital, Ubon Ratchathani, Thailand, 34000. Nicholas P. Day and Sharon J. Peacock, Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, U.K.






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Copyright © 2007 by the American Society of Tropical Medicine and Hygiene.