AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 76(6), 2007, pp. 1194-1200
Copyright © 2007 by The American Society of Tropical Medicine and Hygiene

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ANTIGENIC AND GENETIC RELATIONSHIPS AMONG RIFT VALLEY FEVER VIRUS AND OTHER SELECTED MEMBERS OF THE GENUS PHLEBOVIRUS (BUNYAVIRIDAE)

FANGLING XU, DONGYING LIU, MARCIO R. T. NUNES, AMELIA P. A. TRAVASSOS DA ROSA, ROBERT B. TESH, AND SHU-YUAN XIAO*
Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas; Departamento de Arbovirologia e Febres Hemorragicas, Instituto Evandro Chagas, Ministerio da Saude, Belem, Para, Brazil

Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.

Received December 5, 2006. Accepted for publication March 5, 2007.

Acknowledgments: The sequences obtained in this study have been deposited in GenBank under accession nos. EF076013–EF076027.

Financial support: This work was supported by National Institutes of Health contracts (NO1-AI25489 and NO1-AI30027).

* Address correspondence to Shu-Yuan Xiao, Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0588. E-mail: syxiao{at}utmb.edu

Authors’ addresses: Fangling Xu, Amelia P.A. Travassos da Rosa, Robert B. Tesh, and Shu-Yuan Xiao, Department of Pathology and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0609, Telephone: 409-772-6546, Fax: 409-747-2429, E-mail: syxaio{at}utmb.edu. Dongying Liu, Department of Microbiology, Medical College of Wuhan University, Wuhan, Hubei Province 430071, People’s Republic of China. Marcio R.T. Nunes, Departamento de Arbovirologia e Febres Hemorragicas, Instituto Evandro Chagas, Ministerio da Saude, Belem, Para, Brazil.






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