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HUMAN/VECTOR RELATIONSHIPS DURING HUMAN AFRICAN TRYPANOSOMIASIS: INITIAL SCREENING OF IMMUNOGENIC SALIVARY PROTEINS OF GLOSSINA SPECIES

The morbidity and mortality of vector-borne diseases is closely linked to exposure of the human host to vectors. Qualitative and quantitative evaluation of individual exposure to arthropod bites by investigation of the specific immune response to vector saliva would make it possible to monitor individuals at risk of vectorial transmission of pathogens. The objective of this study was to evaluate and compare the antibody (IgG) response to saliva from uninfected Glossina species, vectors, or non-vectors of Trypanosoma brucei gambiense by detecting immunogenic proteins in humans residing in an area endemic for human African trypanosomiasis in the Democratic Republic of Congo. Our results suggest that the immunogenic profiles observed seemed specific to the Glossina species (vector or non-vector species) and to the infectious status of exposed individuals (infected or not infected). This preliminary work tends to support the feasibility of development of an epidemiologic tool based on this antibody response to salivary proteins.

Received May 31, 2006. Accepted for publication July 31, 2006.

Acknowledgments: We gratefully acknowledge the population of the Bandundu area for participation in the study. We thank G. Cuny for access to tsetse flies bred in an insectarium, A. M, Dupuy and the occupational health team of Lapeyronie Hospital (Montpellier, France) for access to negative sera from personnel who had never been to Africa; and J. P. Brizard for access to the densitometer.

Financial support: The study in the Democratic Republic of Congo was supported by the Institut de Médecine et Epidémiologie Africaine and the Institut de Recherche pour le Développement. Sylvie Cornelie holds a fellowship from the French Fonds Inkerman and the Fondation Singer Polignac, David Courtin holds a fellowship from the French Fondation des Treilles.

^* Address correspondence to Anne Poinsignon, Epidémiologie and Prévention, Unité de Recherche 024, Institut de Recherche pour le Développement, 911 Avenue Agropolis, BP 64501, 34394 Montpellier CEDEX 5, France. E-mail: anne.poinsignon{at}mpl.ird.fr

Authors’ addresses: Anne Poinsignon, Sylvie Cornelie, and Francois Simondon, Epidémiologie and Prévention, Unité de Recherche 024, Institut de Recherche pour le Développement, 911 Avenue Agropolis, BP 64501, 34394 Montpellier CEDEX 5, France, Telephone: 33-4-67-41-63-32, Fax: 33-4-67-41-63-30, E-mails: anne.poinsignon{at}mpl.ird.fr, cornelie{at}mpl.ird.fr, and francois.simondon{at}mpl.ird.fr. Franck Remoue, Epidémiologie and Prévention, Unité de Recherche 024, Institut de Recherche pour le Développement Dakar, Routes des Pères Maristes, BP 1386, 18524 Dakar, Senegal, Telephone 221-849-3555, Fax: 221-832-4307, E-mail: remoue{at}ird.sn. Pascal Grébaut, Laboratoire de Recherche et de Coordination contre les Trypanosomoses, Centre de Coopération International de Recherche Agronomique pour le Développement, Institut de Recherche pour le Développement, Unité Mixte de Recherche 177, Interactions Hôtes-Vecteurs-Parasites dans les Trypanosomoses, TA 207 G, Campus International de Baillarguet, 34398 Montpellier CEDEX 5, France, Telephone and Fax: 33-4-67-59-39-25, E-mail: pascal.grebaut{at}mpl.ird.fr. David Courtin, Unité de Recherche 010, Institut de Recherche pour le Développement, Santé de la Mère et de L’Enfant en Milieu Tropical, Faculté de Pharmacie, 4 Avenue de L’Observatoire, 75270 Paris, France, Telephone: 33-1-53-73-96-17, Fax: 33-1-53-73-96-17, E-mail: d.courtin{at}gmail.com. Andre Garcia, Institut de Recherche pour le Développement Benin, La Résidence Les Cocotiers 08, BP 841 Cotonou, Benin, Telephone: 229-21-30-98-21, Fax: 229-21-95-45-51-14, E-mail: andre.garcia{at}ird.fr.

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