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Am. J. Trop. Med. Hyg., 75(6), 2006, pp. 1106-1107
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


SUCCESSFUL TREATMENT OF BLACK-GRAIN MYCETOMA WITH VORICONAZOLE

PIERRE LOULERGUE*, ARNAUD HOT, ERIC DANNAOUI, ALEXIANE DALLOT, SYLVAIN POIRÉE, BERTRAND DUPONT, AND OLIVIER LORTHOLARY
Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

 

ABSTRACT

Fungal mycetoma (or eumycetoma) are endemic diseases in tropical areas that have economic effects because of their chronic and disabling evolution. Classic treatments include surgery and antifungal drugs, but these have multiple side effects. We report a case of black-grain fungal mycetoma successfully treated with voriconazole without side effects. The duration of the treatment remains unclear, but must be prolonged because of the frequency of relapses.

Received May 19, 2006. Accepted for publication June 28, 2006.

* Address correspondence to Pierre Loulergue, Centre d’Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, 75743 Paris Cedex 15, France. E-mail: pierre.loulergue{at}nck.aphp.fr

Authors’ addresses: Pierre Loulergue, Arnaud Hot, and Bertrand Dupont, Centre d’Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, 75743 Paris Cedex 15, France, Telephone: 33-142-192-623, Fax: 33-142-192-622, E-mails: pierre.loulergue{at}nck.aphp.fr, arnaud.hot{at}nck.aphp.fr, and bertrand.dupont{at}nck.aphp.fr. Eric Dannaoui, Laboratoire de Parasitologie-Mycologie, Georges Pompidou European Hospital, Paris, France, Telephone: 33-1-56-09-39-51, Fax: 33-1-56-09-24-46, E-mail: eric.dannaoui{at}egp.aphp.fr. Alexiane Dallot, Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous Bois, France, Telephone: 33-1-49-36-71-23. Sylvain Poirée, Service de Radiologie, Hôpital Necker-Enfants Malades, Paris, France, E-mail: sylvain.poiree @nck.aphp.fr. Olivier Lortholary, Centre d’Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, 149 Rue de Sèvres, 75743 Paris Cedex 15, France, Telephone: 33-142-192-623, Fax: 33-142-192-622, E-mail: olivier.lortholary{at}nck.aphp.fr and Centre National de Référence Mycologie et Antifongiques, Centre National de la Recher-che Scientifique FRE2849, Pasteur Institute, Paris, France, Telephone: 33-1-45-68-83-55, Fax: 33-1-45-68-84-20, E-mail: olortho{at}pasteur.fr.






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