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Am. J. Trop. Med. Hyg., 75(3), 2006, pp. 470-474
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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CLINICAL FEATURES OF 62 IMPORTED CASES OF DENGUE FEVER IN JAPAN

ICHIRO ITODA*, GOHTA MASUDA, AKIHIKO SUGANUMA, AKIFUMI IMAMURA, ATSUSHI AJISAWA, KEN-ICHIRO YAMADA, SADAO YABE, TOMOHIKO TAKASAKI, ICHIRO KURANE, KYOICHI TOTSUKA, AND MASAYOSHI NEGISHI
Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

To describe the clinical features of dengue cases in Japan, a retrospective study was conducted on 62 laboratory-confirmed Japanese dengue cases presented to Tokyo Metropolitan Komagome Hospital between 1985 and 2000. Age distribution was from 18 to 62 years old (mean, 31.5 years). All cases were imported from abroad and diagnosed as dengue fever. Clinical manifestations included fever (100%), headache (90%), and skin rash (82%). Laboratory examinations revealed leukocytopenia (71%), thrombocytopenia (57%), elevated levels of serum aspartate aminotransferase (78%), and lactate dehydrogenase (71%). Antibody responses were consistent with that of secondary flavivirus infection in 60% of cases. Severity of symptoms in patients with primary dengue antibody response and those with secondary flavivirus antibody responses didn’t show statistical significance. Dengue virus infection should be taken into consideration in the differential diagnosis of febrile patients who recently entered Japan from tropical or subtropical countries.

Received November 4, 2005. Accepted for publication May 16, 2006.

* Address correspondence to Ichiro Itoda, Department of Infectious Diseases, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 1628666, Japan. E-mail: itoda{at}gol.com

Authors’ addresses: Ichiro Itoda and Kyoichi Totsuka, Department of Infectious Diseases, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 1628666, Japan, Telephone: +81-3 3353-8111, Fax: +81-3-3358-8995, E-mail: itoda{at}gol.com. Gohta Masuda, Tokyo Metropolitan Kita Medical and Rehabilitation Center, Tokyo, Japan. Akihiko Suganuma, Akifumi Imamura, Atsushi Ajisawa, and Masayoshi Negishi, Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan. Ken-Ichiro Yamada, Sadao Yabe, Tomohiko Takasaki, and Ichiro Kurane, Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.