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Am. J. Trop. Med. Hyg., 74(3), 2006, pp. 422-424
Copyright © 2006 by The American Society of Tropical Medicine and Hygiene

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AOTUS NANCYMAAE AS A POTENTIAL MODEL FOR THE TESTING OF ANTI-SPOROZOITE AND LIVER STAGE VACCINES AGAINST PLASMODIUM FALCIPARUM

WILLIAM E. COLLINS*, JOANN S. SULLIVAN, ALLISON WILLIAMS, DOUGLAS NACE, TYRONE WILLIAMS, G. GALE GALLAND, AND JOHN W. BARNWELL
Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia; Atlanta Research and Education Foundation, Atlanta, Georgia

The Santa Lucia strain of Plasmodium falciparum was transmitted to Aotus lemurinus griseimembra, A. azarae boliviensis, A. vociferans, and A. nancymaae monkeys by bite and by intravenous inoculation of sporozoites dissected from Anopheles freeborni, An. stephensi, An. gambiae, An. albimanus, and An. maculatus mosquitoes. The data obtained from these infections indicate that A. nancymaae can be considered a suitable host model when combined with the Santa Lucia strain of P. falciparum for the testing of candidate anti-sporozoite and liver stage vaccines.

Received September 2, 2005. Accepted for publication November 6, 2005.

Financial support: This work was supported in part by an interagency agreement between the United States Agency for International Development, Malaria Vaccine Development Program, and the Centers for Disease Control and Prevention, Project # 936-6001, and the Atlanta Research and Education Foundation of the Veterans Affairs Medical Center of Atlanta.

* Address correspondence to William E. Collins, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop F-36, 4770 Buford Highway, Atlanta, GA 30341. E-mail: wec1{at}cdc.gov

Authors’ addresses: William E. Collins, JoAnn S. Sullivan, Douglas Nace, and John H. Barnwell, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop F-36, 4770 Buford Highway, Atlanta, GA 30341, E-mail: wec1{at}cdc.gov. Allison Williams and G. Gale Galland, Animal Resources Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333. Tyrone Williams, Atlanta Research and Education Foundation, VA Medical Center, Atlanta, GA 30033.






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Copyright © 2006 by the American Society of Tropical Medicine and Hygiene.