AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 73(5 suppl), 2005, pp. 50-54
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ZAMORA, F.
Right arrow Articles by HERRERA, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ZAMORA, F.
Right arrow Articles by HERRERA, S.

HEMOGLOBIN LEVELS RELATED TO DAYS OF ILLNESS, RACE, AND PLASMODIUM SPECIES IN COLOMBIAN PATIENTS WITH UNCOMPLICATED MALARIA

FELIPE ZAMORA{dagger}, OSCAR RAMÍREZ{dagger}, JUANA VERGARA, MYRIAM ARÉVALO-HERRERA, AND SÓCRATES HERRERA*
Instituto de Inmunología del Valle, Cali, Colombia; Malaria Vaccine and Drug Development Center, Cali, Colombia; Clinical Research Institute Fundación Clínica Valle del Lili, Cali, Colombia

Prevalence of malaria-related anemia in disease-endemic regions of the American continents has been poorly studied. We describe the relationships between hemoglobin level and race, Plasmodium species, and days of illness in 150 Colombian patients with uncomplicated malaria diagnosed by thick blood smear. Hemoglobin was measured at admission and a standardized questionnaire was used to determine days of illness and other variables. Associations between hemoglobin and the variables were estimated and adjusted according to the other covariates using regression analysis. Plasmodium falciparum and P. vivax were found in similar proportions and mild anemia was present in 50% of the patients. Volunteers were classified as Afro-Colombians (61%) and non-Afro-Colombians (39%). An inverse relationship between hemoglobin and days of illness was identified, and a statistical interaction was found between race and P. falciparum infection in determining the hemoglobin concentration. These observations could guide the design of research to better understand malarial anemia.

Received May 10, 2005. Accepted for publication August 4, 2005.

Acknowledgments: We thank Dr. Bermans Murrain for his advice and collaboration during the evaluation of the patients and Miss Ethel Faye Ruseell for her technical assistance.

Financial support: This work was supported by the John E. Fogarty International Center, National Institutes of Health (grant no. 1D43 TW05885-01).

{dagger} These authors contributed equally to this work.

* Address correspondence to Sócrates Herrera, Malaria Vaccine and Drug Development Center, Carrera 35 No 4A-53, AA 26020, Cali, Colombia. E-mail: sherrera{at}inmuno.org

Authors’ addresses: Felipe Zamora, Juana Vergara, Myriam Arévalo-Herrera, and Sócrates Herrera, Instituto de Inmunología, School of Health, Universidad del Valle, San Fernando, AA 25574, Cali, Colombia, Telephone: 57-2-558-1931, Fax: 57-2-557-0449, and Malaria Vaccine and Drug Development Center, Carrera 35 No 4A-53, AA 26020, Cali, Colombia, Telephone: 57-2-558-3937, Fax: 57-2-556-0141, E-mail: sherrera{at}inmuno.org. Oscar Ramírez, Clinical Research Institute Fundación Clínica Valle del Lili, Cali, Colombia, Telephone: 57-2-331-9090.

Reprint requests: Sócrates Herrera, Malaria Vaccine and Drug Development Center, Carrera 35 No 4A-53, Cali, Colombia.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.