AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 73(5), 2005, pp. 877-880
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


CONCOMITANT PARASITISM: BANCROFTIAN FILARIASIS AND INTESTINAL HELMINTHS AND RESPONSE TO ALBENDAZOLE

PRAKASH K. SAHOO, ASHOK K. SATAPATHY, EDWIN MICHAEL, AND BALACHANDRAN RAVINDRAN*
Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar, India; Department of Infectious Disease Epidemiology, Imperial College of Medicine, London, United Kingdom

 

ABSTRACT

Subjects in an disease-endemic area in Orissa, India concomitantly infected with filariasis and intestinal helminths had significantly lower intensity of filarial infection in comparison with those who were infected only with filariasis. Administration of albendazole resulted in a significant decrease in the prevalence of filarial antigenemia in subjects concomitantly infected with intestinal helminths, but produced little change in this infection measure in subjects infected only with Wuchereria bancrofti. These results indicate that intestinal helminths could play a role in the anti-filarial activity of albendazole, most probably by depressing filarial infection intensity in co-infected individuals. Confirmation of these findings in a larger cohort may yield important new insights regarding the role of using albendazole in the ongoing intervention programs for the control of lymphatic filariasis.

Received June 28, 2004. Accepted for publication April 13, 2005.

Acknowledgments: We thank S. K. Kar, the Director of the Regional Medical Research Centre, Bhubaneswar for sustained support. Edwin Michael is supported by the National Institutes of Health.

Financial support: The Regional Medical Research Centre in Bhubaneswar is funded by the Indian Council of Medical Research, New Delhi.

* Address correspondence to Balachandran Ravindran, Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar 751023, India. E-mail: ravindran8{at}gmail.com

Authors’ addresses: Prakash K. Sahoo, Ashok K.Satapathy, and Balachandran Ravindran, Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar 751023, India, Telephone/Fax: 91-974-230-1399, E-mails: shuvaprakash{at}rediffmail.com, sathapathyak{at}rediffmail.com, and balaravi{at}sancharnet.in and ravindran8{at}gmail.com. Edwin Michael, Department of Infectious Disease Epidemiology, Imperial College of Medicine, Norfolk Place, London W2 1PG, United Kingdom, E-mail: e.michael{at}imperial.ac.uk.

Reprint requests: Balachandran Ravindran, Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Bhubaneswar 751023, India.






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