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Am. J. Trop. Med. Hyg., 73(5), 2005, pp. 839-841
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT


PREVALENCE OF PLASMODIUM FALCIPARUM MUTATIONS ASSOCIATED WITH ANTIMALARIAL DRUG RESISTANCE DURING AN EPIDEMIC IN KUNA YALA, PANAMA, CENTRAL AMERICA

FRANKLYN SAMUDIO, ANA M. SANTAMARÍA, NICANOR III OBALDÍA, JUAN M. PASCALE, VICENTE BAYARD, AND JOSE E. CALZADA*
Instituto Conmemorativo Gorgas de Estudio de la Salud, ICGES, Panama, Republic of Panama

 

ABSTRACT

A molecular epidemiology study was conducted to determine the distribution of antimalarial drug resistance alleles among field isolates of Plasmodium falciparum. Samples were obtained during an epidemic affecting Kuna Amerindians in Panama. A high prevalence of mutations associated with chloroquine, pyrimethamine, and sulfadoxine was observed. Genotype analysis of msp2 revealed a low genetic diversity of P. falciparum parasites circulating in the studied area. The public health implications of these findings for the Central American region are discussed.

Received March 31, 2005. Accepted for publication June 10, 2005.

Acknowledgments: We are grateful to Salomón Puga and Roberto Rojas (Parasitology Section ICGES) for their excellent field work. We also thank the staff from the Vector Control Program, Panamanian Ministry of Health, for their logistical support during the field work.

Financial support: This work was funded by the Gorgas Memorial Foundation Research Grant Award.

* Address correspondence to Jose E. Calzada, Instituto Conmemorativo Gorgas de Estudios de la Salud, apartado Postal 0816-02593, Panamá, República de Panamá. E-mail: jcalzada{at}gorgas.gob.pa

Author’s address: Franklin Samudio, Ana M. Santamaría, Nicanor III Obaldía, Juan M. Pascale, Vicente Bayard, and Jose E. Calzada, Instituto Conmemorativo Gorgas de Estudio de la Salud, apartado Postal 0816-02593, Panamá, República de Panamá, Telephone: (507) 227-4111, Fax: (507) 225-1189.

Reprint requests: José E. Calzado, Instituto Conmemorativo Gorgas de Estudio de la Salud, apartado Postal 0816-02593, Panamá, República de Panamá, E-mail: jcalzada{at}gorgas.gob.pa.






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Copyright © 2005 by the American Society of Tropical Medicine and Hygiene.