AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 73(4), 2005, pp. 705-709
Copyright © 2005 by The American Society of Tropical Medicine and Hygiene

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5-DAY NONOBSERVED ARTESUNATE MONOTHERAPY FOR TREATING UNCOMPLICATED FALCIPARUM MALARIA IN YOUNG GABONESE CHILDREN

NORBERT G. SCHWARZ, SUNNY OYAKHIROME, MARC PÖTSCHKE, BENJAMIN GLÄSER, PETER KLEIN KLOUWENBERG, HANDAN ALTUN, AYOLA A. ADEGNIKA, SAADOU ISSIFOU, JÜRGEN F. J. KUN, PETER G. KREMSNER, AND MARTIN P. GROBUSCH*
Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Gabon; Institute of Tropical Medicine, Department of Parasitology, University of Tübingen, Tübingen, Germany

Despite different recommendations from WHO and national authorities, artesunate monotherapy is increasingly used for treating African children with malaria. A 5-day course of oral artesunate (first day: 4 mg/kg body weight, observed intake; and 2 mg/kg body weight on the following days with nonobserved drug intake) yielded a PCR-corrected Day 28 cure rate of 90% (45 of 50 patients; CI 78–97%) in Gabonese children aged between 2 and 18 months. Artesunate was well tolerated, and no severe adverse events were reported.

Received March 22, 2005. Accepted for publication May 3, 2005.

Acknowledgments: We are grateful to the children and their parents for participation in our longitudinal study. The authors thank Silvelia Grummes for performing the PCR genotyping and all the staff of the Medical Research Unit, the Pediatric Ward and the Maternity Ward of the Albert Schweitzer Hospital for their excellent cooperation.

* Address correspondence to Martin P. Grobusch, University of the Witwatersrand, Infectious Diseases Unit, Johannesburg, South Africa. E-mail: grobuschmp{at}pathology.wits.ac.za.

Authors’ addresses: Norbert G. Schwarz, Sunny Oyakhirome, Marc Pötschke, Benjamin Gläser, Handan Altun, and Saadou Issifou, Medical Research Unit, Albert Schweitzer Hospital, B.P. 118, Lambaréné, Gabon, Telephone: +241581099. Peter Klein Klouwenberg, Ayola A. Adegnika, Jürgen F. J. Kun, Peter G. Kremsner, and Martin P. Grobusch, Institute of Tropical Medicine, Department of Parasitology, Eberhard Karls University, Wilhelmstr. 27, D-72074 Tübingen, Germany, Telephone: +49 7071 298 0234; Fax +49 7071 29 4684.

Reprint requests: Martin P. Grobusch, University of the Witwatersrand, Infectious Diseases Unit, Johannesburg, South Africa, Telephone: +2711 489 8537; Fax: +2711 489 8530, E-mail: grobuschmp{at}pathology.wits.ac.za.






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