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GENETIC POLYMORPHISMS OF EOSINOPHIL-DERIVED NEUROTOXIN AND EOSINOPHIL CATIONIC PROTEIN IN TROPICAL PULMONARY EOSINOPHILIA

Because eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) are critical in the pathogenesis of tropical pulmonary eosinophilia (TPE), we analyzed genetic polymorphisms of both in 181 individuals from southern India with varying clinical manifestations of Wuchereria bancrofti infection (including 26 with TPE). Using haplotype frequency analysis, we identified four known (of nine) and two novel haplotypes for EDN (1, 2, 7, 8, 10, and 11). For ECP, five (of seven known) haplotypes (1–5) were identified. Although we found no significant association between frequencies of EDN and ECP polymorphisms and TPE development, we observed a unique pattern of EDN and ECP polymorphism distribution among this population. Genotype TT at locus 1088 of ECP in one TPE patient was not observed in any other clinical group. Although the EDN and ECP polymorphisms appear unlikely to be associated with the development of TPE, further analyses will be more definitive.

Received December 6, 2004. Accepted for publication December 28, 2004.

Acknowledgment: We thank Brenda Rae Marshall for editorial assistance

^* Address correspondence to Yae-Jean Kim, Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 4 Center Drive, Building 1, Room B1-07, Bethesda, MD 20892. E-mail: yjkim{at}niaid.nih.gov

Authors’ addresses: Yae-Jean Kim and Thomas B. Nutman, Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 4 Center Drive, Building 1, Room B1-07, Bethesda, MD 20892, E-mail: tnutman{at}niaid.nih.gov. V. Kumarswami, Tuberculosis Research Centre, Chennai, India. Eunhwa Choi, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. Jianbing Mu, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, NIAID, Bethesda, MD 20892. Dean A. Follmann, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Peter Zimmerman, Center for Global Health and Diseases, Case Western Reserve University, University Hospitals of Cleveland, School of Medicine, Cleveland, OH 44106.