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Am. J. Trop. Med. Hyg., 70(2), 2004, pp. 144-148
Copyright © 2004 by The American Society of Tropical Medicine and Hygiene

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SHORT REPORT: MODULATION OF MYCOBACTERIUM TUBERCULOSIS INFECTION BY PLASMODIUM IN THE MURINE MODEL

CHERISE P. SCOTT, NIRBHAY KUMAR, WILLIAM R. BISHAI, AND YUKARI C. MANABE
Department of International Health, and Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland

 

ABSTRACT

A large proportion of people with latent tuberculosis live in malaria-endemic areas, so co-infection with these two organisms is likely to be common. To determine whether there might be a biologic interaction between these two pathogens in vivo, we infected mice with Mycobacterium tuberculosis and then with a non-lethal strain of Plasmodium yoelii eight weeks later. Mice chronically infected with M. tuberculosis simulate the equilibrium between pathogen and host thought to exist in human latent infection. Co-infected mice were less able to contain growth of M. tuberculosis in lung, spleen, and liver (mean ± SEM log10 colony-forming units = 5.50 ± 0.11 versus 5.12 ± 0.08, 4.58 ± 0.07 versus 4.13 ± 0.10, and 2.86 ± 0.10 versus 2.49 ± 0.10, respectively) and had increased mortality. In populations where both diseases are endemic, there may be implications for increased incidence of clinically detectable tuberculosis.

Received October 24, 2003. Accepted for publication November 14, 2003.

Acknowledgments: We thank Tetsuyuki Yoshimatsu, Amy Cernetich, and Greg Noland for technical assistance with photography and parasitemia assessment. Grateful thanks are also extended to JoAnne Flynn and Holly Scott for their methodologic assistance with organ T cell analysis and intracellular cytokine staining.

Financial support: This work was supported by National Institutes of Health Grants AI-01689-01, AI-36973, and AI-37856, and a grant from the Johns Hopkins Malaria Research Institute.

Authors’ addresses: Cherise P. Scott and Nirbhay Kumar, Department of Molecular Immunology and Microbiology, Johns Hopkins Bloomberg School of Public Health, Room E5144, 615 North Wolfe Street, Baltimore, MD 21205, Telephone: 410-955-7177, E-mails: chscott{at}jhsph.edu and nkumar{at}jhsph.edu. William R. Bishai, Center for Tuberculosis Research, Johns Hopkins School of Medicine, 1503 East Jefferson Street, Room 112, Baltimore, MD 21231-1002, Telephone: 410-955-3150, Fax: 410-614-8173, E-mail: wbishai1{at}jhmi.edu. Yukari C. Manabe, Center for Tuberculosis Research, Johns Hopkins School of Medicine, 1503 East Jefferson Street, Room 108, Baltimore, MD 21231-1002, Telephone: 410-614-6600, Fax: 410-614-8173, E-mail: ymanabe{at}jhmi.edu.

Reprint requests: Yukari C. Manabe, Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1503 East Jefferson Street, Room 108, Baltimore, MD 21231-1002.




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