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EVALUATION OF THE BINAX NOW^® ICT TEST VERSUS POLYMERASE CHAIN REACTION AND MICROSCOPY FOR THE DETECTION OF MALARIA IN RETURNED TRAVELERS

Microscopic detection of Plasmodium species has been the reference standard for the diagnosis of malaria for more than a century. However, maintaining a sufficient level of expertise in microscopic diagnosis can be challenging, particularly in non-endemic countries. The objective of this study was to compare a new rapid malaria diagnostic device (NOW^® ICT Malaria Test; Binax, Inc., Portland, ME) to polymerase chain reaction (PCR) and expert microscopy for the diagnosis of malaria in 256 febrile returned travelers. Compared with PCR, the NOW^® ICT test showed a sensitivity of 94% for the detection of P. falciparum malaria (96% for pure P. falciparum infection) and 84% for non-P. falciparum infections (87% for pure P. vivax infections and 62% for pure P. ovale and P. malariae infections), with an overall specificity of 99%. The Binax NOW^® ICT may represent a useful adjunct for the diagnosis of P. falciparum and P. vivax malaria in febrile returned travelers.

Received July 16, 2003. Accepted for publication September 5, 2003.

Financial support: This study was supported in part by a grant from the Canadian Institutes of Health Research (CIHR MT-13721 to Kevin C. Kain). Kevin C. Kain is supported by a Career Scientist Award from the Ontario Ministry of Health and a Canada Research Chair (CIHR).

Authors’ addresses: Gabriella A. Farcas, Kathleen J. Y. Zhong, and Fiona E. Lovegrove, Medical Sciences Building 7318, University of Toronto, 1 King’s College Circle, Toronto, Ontario, Canada M5S 1A8. Christopher M. Graham and Kevin C. Kain, Tropical Disease Unit, EN G-224, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4, E-mail: kevin.kain{at}uhn.on.ca.

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