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Am. J. Trop. Med. Hyg., 69(5), 2003, pp. 506-508
Copyright © 2003 by The American Society of Tropical Medicine and Hygiene

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ASSOCIATION OF VIRULENCE FACTOR-POSITIVE AND -NEGATIVE ENTEROAGGREGATIVE ESCHERICHIA COLI AND OCCURRENCE OF CLINICAL ILLNESS IN TRAVELERS FROM THE UNITED STATES TO MEXICO

DAVID B. HUANG, ZHI-DONG JIANG, AND HERBERT L. DUPONT
Department of Medicine, Baylor College of Medicine, Houston, Texas; Center for Infectious Diseases, University of Texas-Houston School of Public Health and Medical School, Houston, Texas; St. Luke’s Episcopal Hospital, Houston, Texas

The objective of the study was to determine if the presence or absence of virulence factor-positive and -negative enteroaggregative Escherichia coli (EAEC) determined the occurrence of illness or sub-clinical EAEC infection in travelers from the United States to Mexico. Sixty-five newly arrived college students from the United States submitted weekly stool samples for a four-week period of time. Among EAEC-infected subjects, diarrhea occurred in those with a defined virulence factor with the following frequency: aggA, 5 of 15 (33%); aggR, 3 of 11 (27%); aafA, 3 of 8 (38%); and aspU, 1 of 6 (17%). Twenty-two of 31 students (71%) had two or more EAEC infections. After the initial EAEC infection, only 4 (11%) of 31 students had a subsequent symptomatic EAEC infection. Our study suggests that clinical illness by EAEC is not explained by presence of a defined EAEC virulence factors, and we provide suggestive evidence that EAEC infection protects against future symptomatic infection.

Received June 16, 2003. Accepted for publication August 20, 2003.

Authors’ addresses: David B. Huang, Department of Medicine, Baylor College of Medicine, 1 Baylor Plaza, BCM 286, Room N1319, Houston, TX 77030, Telephone: 832-355-4122, Fax: 832-355-4167, E-mail: dhuang1{at}bcm.tmc.edu. Zhi-Dong Jiang, University of Texas School of Public Health, 1200 Herman Pressler, Room 706, Houston TX 77030 and University of Texas-Houston Medical School, 1200 Herman Pressler, Room W703, Houston, TX 77030, E-mail: zjiang{at}sph.uth.tmc.edu. Herbert L. DuPont, St. Luke’s Episcopal Hospital, 6720 Bertner Avenue, MC -1-164, Houston, TX 77030, E-mail: hdupont{at}sleh.com.






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