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SERUM CYTOKINE PROFILES IN PATIENTS WITH PLASMODIUM VIVAX MALARIA: A COMPARISON BETWEEN THOSE WHO PRESENTED WITH AND WITHOUT HYPERPYREXIA

Serum cytokine profiles in patients with Plasmodium vivax malaria who presented with and without hyperpyrexia were compared by a retrospective review of the medical records of the consecutive patients seen at the military hospitals near the demilitarized zone in the Republic of Korea from April 2000 through October 2001. Of 162 male patients studied, 120 (86.4%) presented with hyperpyrexia (i.e., an axillary temperature 40°C). The mean ± SEM ages of the patients with and without hyperpyrexia were 21.5 ± 0.14 and 21.9 ± 0.39 years, respectively (P = 0.33). The mean ± SEM concentrations of serum interleukin (IL)-6 (379.7 ± 44.1 pg/mL versus 105.4 ± 26.8 pg/mL; P = 0.002), IL-10 (583.4 ± 58.2 pg/mL versus 142.4 ± 39.7 pg/mL; P = 0.0001), and interferon- (312.6 ± 33.9 pg/mL versus 112.9 ± 27.1 pg/mL; P = 0.0001) were significantly higher in patients with hyperpyrexia compared with those without hyperpyrexia. The mean ± SEM concentrations of serum tumor necrosis factor- were 155.5 ± 54.5 pg/mL and 109.9 ± 29.3 pg/mL (P = 0.27) in patients who presented with and without hyperpyrexia, respectively. Further studies are needed to examine whether serum concentrations of these cytokines also parallel their concentrations at the tissue sites of their production and action.

Received February 7, 2002. Accepted for publication July 29, 2002.

Acknowledgments: This study was supported by a grant from the Korea Health 21 R&D Project (Ministry of Health and Welfare, Republic of Korea, 02-PJ1-PG10-21204-0001).

Authors’ addresses: Ju-Young Seoh, Mohammad Khan, Hae-Kyung Park, Myong-Heon Shin, Eun-Hee Ha, Bo-Eun Lee, Kwon Yoo, and Ho-Seong Han, Department of Microbiology, Parasitology, Preventive Medicine, Internal Medicine, and Surgery, College of Medicine, Ewha Womans University, Seoul, Korea. Se-Ho Park, Graduate School of Biotechnology, Korea University, Seoul, Korea. Sejoong Oh, Jun-Hwan Wi, and Chang-Kwon Hong, Korean Armed Forces Medical Command, Seongnam, Korea. Chang-Hyun Oh, Young-A Kim, and Jae-Won Park, Department of Microbiology, Gachon Medical School, 1198, Kuwoldong, Namdonggu Inchon 405-760, Korea, Telephone: 82-32-460-2184, 82-32-930-5095, Fax: 82-32-930-5088, E-mail: seorak{at}dreamwiz.com

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