AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 65(5), 2001, pp. 567-572
Copyright © 2001 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neva, F.
Right arrow Articles by Pelletier, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neva, F.
Right arrow Articles by Pelletier, L.
Related Collections
Right arrow Strongyloidiasis
Right arrow Travel Medicine
American Journal of Tropical Medicine and Hygiene, Vol 65, Issue 5, 567-572
Copyright © 2001 by American Society of Tropical Medicine and Hygiene

Research Articles


Skin test antigens for immediate hypersensitivity prepared from infective larvae of Strongyloides stercoralis

FA Neva, AA Gam, C Maxwell, and LL Pelletier

More rapid and simplified diagnostic procedures are needed for the diagnosis of strongyloidiasis. One approach is the use of an immediate hypersensitivity skin test that would reliably identify infected people. Accordingly, somatic and excretion/secretion (E/S) antigens were prepared from filariform larvae of Strongyloides stercoralis and were treated to remove possible adventitious agents. By use of a quantitative method for measurement of skin reactions, several preparations of the 2 antigens were tested in uninfected controls and in various groups of patients. Doses of 0.35 microg of E/S and 4 microg of somatic antigens elicited positive skin tests in 82-100% of infected people, depending on clinical status. A lower frequency of positive skin tests was found in strongyloidiasis patients also infected with human T-cell lymphotropic virus type 1. Cross-reactions, especially to somatic antigens, were frequently found in patients with filarial infections. Despite these limitations and the need for further study of specificity, these results provide a basis for future development of a diagnostic skin test antigen for strongyloidiasis.


This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
J. Sithithaworn, P. Sithithaworn, T. Janrungsopa, K. Suvatanadecha, K. Ando, and M. R. Haswell-Elkins
Comparative Assessment of the Gelatin Particle Agglutination Test and an Enzyme-Linked Immunosorbent Assay for Diagnosis of Strongyloidiasis
J. Clin. Microbiol., July 1, 2005; 43(7): 3278 - 3282.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
V. RAVI, T. P. KING, J. F. ANDERSEN, T. B. NUTMAN, and F. A. NEVA
STRONGYLOIDES STERCORALIS RECOMBINANT NIE ANTIGEN SHARES EPITOPE WITH RECOMBINANT Ves v 5 AND Pol a 5 ALLERGENS OF INSECTS
Am J Trop Med Hyg, May 1, 2005; 72(5): 549 - 553.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
P. B. Keiser and T. B. Nutman
Strongyloides stercoralis in the Immunocompromised Population
Clin. Microbiol. Rev., January 1, 2004; 17(1): 208 - 217.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Society of Tropical Medicine and Hygiene.